Studs interviews blues singers Willie Dixon, Sunnyland Slim, and Willie Mae Big Mama Thornton about the blues. They discuss the blues festival in Chicago for which they are all in town for and name other musicians who will be performing. Sunnyland Slim talks about being on the road and the hard times. Thornton describes the blues as music made from life experiences.

Studs interviews Willie Dixon and Koko Taylor about the blues. They discuss their song "Insane Asylum" and their work together. Dixon uses his song "Little Red Rooster" to help explain how the blues are created from life experiences. Taylor reflects on singers like Willie Dixon, Memphis Minnie, and others who influenced her desire to sing the blues. Taylor also discusses European audiences and blues influence there. The musical numbers are removed from this edited version of the original recording.

Langston Hughes, John Sellers, James Cotton, and Otis Spann discuss their origins and blues music. The interview focuses heavily on Langston Hughes and how deeply he is influenced by the blues. Hughes also discusses his upcoming book "An African Treasury" at length. Hughes, Sellers, Spann, and Cotton perform a number of songs during the interview, they have been removed due to copyright.

Studs interviews Brother John Sellers about his career and other blues singers. Sellers explains that religion influenced his music as did performers like Mahalia Jackson, Big Bill Broonzy, and Muddy Waters. Studs reads some of the lyrics of blues song, "In the Evening." Sellers describes street singers and blind singers. He describes the music and style of Jackson and Broonzy and some of his own songs. Sellers performs "Talk About A Child" and "Sally Go Round the Sunshine" live on the program.