Brownie McGhee and Sonny Terry discuss their careers as blues musicians and longtime collaborators. The close relationship between Terry and McGhee is apparent as they perform a number of original and traditional songs during the interview. Songs have been removed due to copyright.

Studs interviews Brother John Sellers about his career and other blues singers. Sellers explains that religion influenced his music as did performers like Mahalia Jackson, Big Bill Broonzy, and Muddy Waters. Studs reads some of the lyrics of blues song, "In the Evening." Sellers describes street singers and blind singers. He describes the music and style of Jackson and Broonzy and some of his own songs. Sellers performs "Talk About A Child" and "Sally Go Round the Sunshine" live on the program.

Art Hodes discusses his history and influences on his career as a jazz and blues pianist. He tells stories of musicians he has worked with and how he keeps his performances fresh after playing for so many years. Music by Art Hodes is played throughout: "Chimes Blues", "Tennessee Waltz", "Grandpa's Spells", "Just a Closer Walk with Thee","Cakewalkin' Babies from Home", "Blues 'N Booze", and "Riverside Blues".