Blind John Davis, Chicago blues pianist, discusses his time playing in Germany and at the Blue Note jazz club, chitlin' parties, growing up on the West side of Chicago. He also recalls meeting and working with musicians like Tampa Red and Big Bill Broonzy. Music by John Davis (unless noted as another artist) is played throughout : "Jim Town Blues", "Every Day I Got the Blues", "Pine Top's Boogie Woogie", "Summertime", "Looking Up at Down"- Big Bill Broonzy, "Killer Diller Blues"- Memphis Minnie, "Moanin' the Blues", "When I Lost My Baby", and "Magic Carpet".

Studs interviews Willie Dixon and Koko Taylor about the blues. They discuss their song "Insane Asylum" and their work together. Dixon uses his song "Little Red Rooster" to help explain how the blues are created from life experiences. Taylor reflects on singers like Willie Dixon, Memphis Minnie, and others who influenced her desire to sing the blues. Taylor also discusses European audiences and blues influence there. The musical numbers are removed from this edited version of the original recording.

Studs interviews blues singers Willie Dixon, Sunnyland Slim, and Willie Mae Big Mama Thornton about the blues. They discuss the blues festival in Chicago for which they are all in town for and name other musicians who will be performing. Sunnyland Slim talks about being on the road and the hard times. Thornton describes the blues as music made from life experiences.